This is why no one can figure out that we ARE actually sick. Tolerance and cross-tolerance

“Tolerance means the immune system will stop responding to the antigen. Cross tolerance means spreading or expanding normal disease-combating insufficiency to other antigen types such as TLR4 agonists or TLR7/9 agonists (viruses). Exposure to shed borrelial lipoproteins causes fungal tolerance in the blood and the inability to get rid of mycoplasma/eperythrozoons (also bearers of fungal antigens like OspA) from the blood, especially from the red blood cells. It is well known that fungi infections in the blood, particularly these blood parasites, the eperythrozoa or mycoplasma, causes fatigue, because they, by attaching to the surfaces of- and within- red blood cells hijack sugar metabolism and change the osmotic potential of the red cell membrane, rendering Oxygen unable to cross the red cell membrane, starving the body cells of Oxygen.

This generalized immunosuppression as a result of exposure to borreliae and their shed varying surface antigens creates an environment where common opportunistic infections are reactivated, such as latent Epstein-Barr, and cause chronic disabling disease.” -KMD

Tolerance and cross-tolerance is the reason that someone can have an illness without classic inflammation.  It means that your body has lost the ability to have an inflammatory or immune response and that’s really all doctors have been trained to detect.  It means that your germinal centers (lymph nodes) are wrecked.  Your bodies defense mechanism has been plagued with what you can only liken to a zombie apocalypse.  The relationship sepsis has with hyporesponsiveness is known, although doctors appear to be the last to know.

“A similar pattern of hyporesponsiveness was observed during sepsis that may represent a mechanism for modulating the inflammatory response during severe infections.”

Hypo means under or low or below normal.  This dampened or underwhelming or nonexistent immune response to pathogens is the real disease when it comes to borrelia infections.  It happens with other diseases as well.  This is why no one gets positive tests on anything, because if you’re measuring the immune response in someone who is immune suppressed they just simply aren’t going to have one.  This is where doctors fail their patients.  This is where the criminals get away with murder.

TLR 2/1 agonists cause this.  Some examples are OspA, mycoplasma or eperythrozoa.

great imitator ospa


”This finding suggests that there is redundancy in the ability of the innate immune system to recognize B. burgdorferi and/or that these components can activate pathways that produce anti-inflammatory cytokines, … – the anti-inflammatory effects might be the more important function of TLR signaling.”


“The anti-inflammatory effects might be more important…”

This is what TruthCures has been saying the whole time.  Viruses reactivating in the presence of immunosuppression is the RULE, never the exception.  We know that borrelia possess this capability due to OspA being an endotoxin worse than LPS causing tolerance and cross tolerance in the immune system because everyone says so.  The common mechanisms Charge Sheet is full of examples so I recommend everyone read that for more than I am able to include in this blog.  This class of  diseases are all about the fungal/viral synergy.

Cross tolerance means you lack the ability to recognize and fight other pathogens.  So does endotoxin tolerance.  So does post sepsis, and immunosuppression and having an “overwhelmed immune system” as Steere puts it.  This is what people are losing their lives over.  They can’t get diagnosed with ANYTHING because their bodies are literally not CAPABLE of producing the inflammation that doctors look for.  So you can see how big of a problem this is.  They say that if you don’t produce antibodies, if you don’t mount an immune response, you are not actually sick, you are just crazy.  But what I am showing you right now is the contrary, that you are SICKER if you don’t have the inflammatory kind of lyme AKA bad knee.  It is important for us all to understand this one thing-

You can have a disease without inflammation.  In fact, these diseases are worse and the patients are much sicker.  Doctors don’t know how to diagnose or treat them and that’s the problem.  No one wants to talk about it because it betrays the way vaccines are supposed to work and would expose the most horrendous medical crymes in history.

iceberg illness model

Here is Dattwyler at the FDA meeting saying that the lower the immune response the sicker the patient:

“Individuals with a poor immune response tend to have worse disease”

Here is Wormser saying that OspA alone causes serious problems and the severity of disease is directly correlated to how much exposure you get:

wormser ospa

“The magnitude of modulation was directly dependent on the quantity of OspA.  OspA interferes with the response of lymphocytes to proliferative stimuli including a blocking of cell cycle phase progression.”

Here we are seeing that yes, borrelia does in fact make it so that you cannot mount an immune response or recognize other pathogens.  It is the opportunistics or the secondary infections that are doing all of the damage.  This is not about spirochetes.  Spirochetes shed or bleb OspA, which is a TLR 2/1 agonist, an endotoxin, and it destroys your bodies ability to recognize fungi, viruses, parasites, bacteria….etc.

“….we propose that TLR2 signaling induces rapid depletion of IRAK1, which impairs IFN-I induction by TLR7/9. This novel mechanism, whereby TLR2 inhibits IFN-I induction by TLR7/9, may shape immune responses to microbes that express ligands for both TLR2 and TLR7/TLR9, or responses to bacteria/virus coinfection.”

“Next, we investigated whether these Borrelia-specific stimuli render monocytes tolerant, i.e. hyporesponsive, towards another Toll-like receptor 2 (TLR2) agonist, such as lipoteichoic acid from gram-positive bacteria, or towards the TLR4 agonist lipopolysaccharide. Cross-tolerance towards all tested stimuli was induced. Furthermore, using primary bone marrow cells from TLR2-deficient mice and from mice with a nonfunctional TLR4 (strain C3H/HeJ), we demonstrated that the TLR2 was required for tolerance induction by Borrelia, and using neutralizing antibodies, we identified interleukin-10 as the key mediator involved.”    

Why is it worse to have to have a disease like this?  Because it means that you’re a zombie on a cellular level.  It means that you’re 80 years old on a cellular level.  It means that you are the sickest of the sick.  It means that you are the walking dead.  It means that  taking antibiotics can’t fix this, not that you can kill spirochetes anyway.   This is what post sepsis syndrome is.

The problems last a lifetime.  Killing pathogens in your body does not reverse it, neither does eating right, or thinking positive, or taking herbs.  None of this fixes damaged B cells or changes anything in the lymph nodes.  These victims are sick and it’s not about inflammation.  It never was and the criminals knew this before 1990 when they were publishing about what they found in our spinal fluid, and it wasn’t a spirochete or biofilm they saw.

Duray cancer:lyme

“The plasma cell precursors are large, appear tumor-like, and can resemble Reed-Sternberg cells. Others look like typical immunoblasts (FIG. 1). In one example, cervical lymph nodes show cell degeneration with karyorrhexis and nuclear debris of lymphoid elements. This patient had repeated high fevers and marked discomfort of neck nodes. Large atypical immunoblasts can also be seen in the spleen and bone marrow. The red pulp of the spleen is congested, not unlike that seen in infectious mononucleosis. Spirochetes can be demonstrated in the lymph nodes, spleen and bone marrow and liver.” 

“Experiments with TLR2-knockout mice confirmed that the inhibitory effects of Pam3Cys depend on the expression of TLR2.” “Pam3Cys keeps the precursors on a more immature stage.” ” TLR2 arrests/retards that process, ascribing new roles for TLRs in B cell physiology.”

This is the result.  It is the opportunistics or the secondary infections that are doing all of the damage.  This is not about spirochetes.  They do all their damage in the first week, after that it’s this tolerance and cross-tolerance business that is the true issue.  Spirochetes shed or bleb OspA, which is a TLR 2/1 agonist, an endotoxin, and it destroys your bodies ability to recognize fungi, viruses, parasites, bacteria….etc.

All of this abuse, all of this suffering, can be ended.  Lets get the b@stards.  Knowing this stuff and exposing it is how we are going to win this thing.  The truth, facts and science cannot be won against.  SAYS THE CROOKS THEMSELVES.  They say they can’t win on a scientific front themselves, so lets all make it a point to know this stuff and win.

DurlandFish FOIA email

This is what I’ve attempted to show you:

  • Tolerance and cross-tolerance are when your body loses the ability to recognize or fight pathogens.
  • This is why we don’t produce inflammation and this is what gives the criminals the power to say that we are not sick, just crazy.
  • Yet there is plenty of evidence to the contrary that we are VERY sick, doctors just don’t know how to use PubMed and they aren’t scientists.  Plus this is a cryme scene and that’s why we don’t hear the CDC talking about this.
  • This is a very serious disease and its no wonder we all feel like we are dying.
  • The disease is really all about post sepsis with wrecked germinal centers and bad B cells.  The disease is like AIDS and cancer, it’s not just a chronic bacterial infection.
  • This is why antibiotics or herbs or positive thinking doesn’t work.  Nothing oral can fix this.

Read HERE for what hypothetical treatment might work after the prosecution.  Click HERE for more information.  Click HERE if you want to join our movement and get updates conveniently on Facebook.



12 thoughts on “This is why no one can figure out that we ARE actually sick. Tolerance and cross-tolerance

  1. Pingback: “Nutrition” Carpet-Baggers and other “Lyme = B cell AIDS” Opportunists. | Cryme Disease - Unscrambling the CDC's DNA Patent Profiteering Bullshit

  2. Pingback: You can get “Chronic Lyme” from just OspA, you don’t even need the whole spirochete to have your life ruined. |

  3. Pingback: “Lyme” disease is like CANCER and AIDS says the “Experts” |

  4. “Nothing oral can fix this”. Well, oral medications, especially anti-parasitic herbs and drugs, along with LDN, have improved me so much that I feel wonderful and doctors now question my MS/Lyme diagnosis.


  5. Thank you for this website – very interesting about the OspA. I understand your anger and frustration – felt this way many times, and still do. Let’s look for the answer ourselves! Share info on what does help us! None of us get out of here alive.


    • Hi Merry,

      So many are not able to see a LLMD or self treat, plus none of the available treatments fix B cells. We have thousands of homeless victims, people literally starving to death and dying of exposure because they couldn’t get disability. We need to focus on the big picture. There are 2 million people contracting this disease every single year, half of them becoming disabled eventually. So 1 million new patients this year, and the year after that, and the year after that, and the year after that…..

      A lot of us have spent all of our money and tried everything that is out there and are still sick. Look at all of the celebrities and other wealthy people who have traveled the world in search of relief and are still sick. All the money in the world can’t save them and it’s because this isn’t just a chronic bacterial infection. This is AIDS. Post sepsis syndrome. Lymephoma. Half the cases fail even early treatment. Spirochetes do all of the damage within the first 10 days and are found in the lymph nodes in as little as 48 hours. Game over.

      I am outraged at the atrocity and using that anger to fight back on behalf of everyone. We need more of that or things will remain the same. Don’t settle for a situation in which thousands of people are being left to fend for themselves while being tortured to death, stand up and demand justice. You’re right, none of us get out of here alive but every human deserves to at least die with dignity. There are children involved and they deserve better. The answer that slapped me in the face is a criminal prosecution to help ourselves, so that is what I share.

      Liked by 1 person

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